The foundation of any smart city requires an innovative and robust communication infrastructure. Many research communities envision free-space optical communication (FSO) as a promising backbone technology for the services and applications provided by such cities. However, the channel through which the FSO signal travels is the atmosphere. Therefore, the FSO performance is limited by the local weather conditions. The variation in meteorological variables leads to variations of the refractive index along the transmission path. These index inhomogeneities (i.e., atmospheric turbulence) can significantly degrade the performance of FSO systems. Thus, a practical implementation of the FSO link must carefully consider the atmospheric turbulence effect. This paper aims to investigate the feasibility of FSO communication for NEOM, a promising smart city in Saudi Arabia. We study the effect of weather conditions on FSO links using the micrometeorology model, taking into account actual weather data. The FSO performance in winter and summer was compared in terms of the bit error rate, signal-to-noise ratio (SNR), link availability, and transmission distance. The study shows that the atmospheric turbulence strength is moderate and strong in winter and summer, respectively. The temperature has the biggest impact on the FSO system when compared to the other meteorological elements included in this study. Furthermore, at transmission distances less than 300 m, atmospheric turbulence does not significantly affect the FSO for the operating wavelength of 1550 nm. Furthermore, it has been shown that at transmission distances greater than 300 m, the SNR in summer is more than 18% higher than in winter. The findings of this research enable understanding of the effect of turbulence caused by NEOM weather on the FSO link, thus assisting engineers in establishing a reliable FSO backbone link by adjusting the relevant parameters.